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Effects of Low-carbohydrate and High-fat Diet Supplemented with Ketogenic Drink on Cognitive Function and Physical Performance in the Elderly at High Risk for Dementia
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Eun Ji Kim, Jung Sik Park, Won Sun Choi, Yoo Kyoung Park
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Korean J Community Nutr 2019;24(6):525-534. Published online December 31, 2019
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DOI: https://doi.org/10.5720/kjcn.2019.24.6.525
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 Abstract
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- OBJECTIVES
Reduced glucose utilization in the main parts of the brain involved in memory is a major cause of Alzheimer's disease, in which ketone bodies are used as the only and effective alternative energy source of glucose. This study examined the effects of a low-carbohydrate and high-fat (LCHF) diet supplemented with a ketogenic nutrition drink on cognitive function and physical activity in the elderly at high risk for dementia.
METHODS
The participants of this study were 28 healthy elderly aged 60-91 years showing a high risk factor of dementia or whose Korean Mini-Mental State Examination (K-MMSE) score was less than 24 points. Over 3 weeks, the case group was given an LCHF diet with nutrition drinks consisting of a ketone/non-ketone ratio of 1.73:1, whereas the control group consumed well-balanced nutrition drinks while maintaining a normal diet. After 3 weeks, K-MMSE, body composition, urine ketone bodies, and physical ability were all evaluated.
RESULTS
Urine ketone bodies of all case group subjects were positive, and K-MMSE score was significantly elevated in the case group only (p=0.021). Weight and BMI were elevated in the control group only (p<0.05). Grip strength was elevated in all subjects (p<0.01), and measurements of gait speed and one leg balance were improved only in the case group (p<0.05).
CONCLUSIONS
We suggest that adherence to the LCHF diet supplemented with a ketogenic drink could possibly influence cognitive and physical function in the elderly with a high risk factor for dementia. Further, we confirmed the applicability of this dietary intervention in the elderly based on its lack of any side effects or changes in nutritional status.
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Citations
Citations to this article as recorded by  - To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease
Maria G Grammatikopoulou, Dimitrios G Goulis, Konstantinos Gkiouras, Xenophon Theodoridis, Kalliopi K Gkouskou, Athanasios Evangeliou, Efthimis Dardiotis, Dimitrios P Bogdanos
Advances in Nutrition.2020; 11(6): 1583. CrossRef
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