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Association of Plasma Osteoprotegerin with Adiponectin and Difference according to Obesity in Men with Metabolic Syndrome
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Original Article
Association of Plasma Osteoprotegerin with Adiponectin and Difference according to Obesity in Men with Metabolic Syndrome
Woori Na, Cheongmin Sohn
Korean Journal of Community Nutrition 2011;16(6):762-770.
DOI: https://doi.org/10.5720/kjcn.2011.16.6.762
Published online: December 31, 2011

Major in Food and Nutrition, Wonkwang University, Iksan, Korea.

Corresponding author: Cheongmin Sohn, Major in Food and Nutriton, Wonkwang University, 344-2 Sinyong-Dong, Iksan, Jeonbuk 570-749, Korea. Tel: (063) 850-6656, Fax: (063) 850-7301, ccha@wku.ac.kr
• Received: November 10, 2011   • Revised: December 2, 2011   • Accepted: December 5, 2011

Copyright © 2011 The Korean Society of Community Nutrition

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  • Osteoprotegerin (OPG) plays a core role in bone reformation by antagonizing the effect of receptor activator of nuclear factor κ-B ligand (RANKL), and mediates vascular calcification in cardiovascular disease patients. Thus, we aimed to examine the relationship between serum OPG levels and cardiovascular factors and inflammatory markers in metabolic syndrome patients (MS). This cross-sectional study included 96 men who visited the diet clinic between May and July 2011. Patients were classified into 2 groups based on NCEP-ATP guidelines: normal and with MS (n = 50 and 46, respectively). Physical measurements, biochemical assay were measured. Serum OPG and IL-6, diponectin and hs-CRP were assessed. MS were aged 50.02 ± 10.85 years, and normal patients 52.07 ± 9.56 years, with no significant differences. Significant differences were not observed in BMI between the 2 groups. Moreover, significant differences were not observed in serum OPG, however, the serum OPG level (4.41 ± 1.86 pmol/L) differed significantly between an overweight MS (BMI > 25) and normal patients. OPG was correlated to age (r = 0.410, p = 0.000), HDL-cholesterol (r = 0.209, p = 0.015), and log adiponectin (r = 0.175, p = 0.042). Multiple regression analyses using the enter method showed that age (β = 0.412, p = 0.000) and BMI (β = 0.265, p = 0.000) considerably affected OPG. In conclusion, out study showed that serum OPG levels are correlated with cardiovascular risk factors, such as BMI, HDL-cholesterol and adiponectin in MS and adiponectin, suggesting that serum OPG has potential as a cardiovascular disease indicator and predictor.
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Fig. 1
Difference of OPG levels between MS group and control group according to body mass index.
kjcn-16-762-g001.jpg
Table 1
General characteristics and metabolic syndrome indicators of the subjects
kjcn-16-762-i001.jpg

1) Mean ± SD, 2) BMI: Body mass index, 3) WC: Waist circumference, 4) FPG: Fasting plasma glucose, 5) HDL-Chol: High-density lipoprotein cholesterol, 6) SBP: Systolic blood pressure, 7) DBP: Diastolic blood pressure

Significantly different at **: p < 0.01, ***: p < 0.001 by t-test

Table 2
Risk factors for cardiovascular disease and inflammatory markers
kjcn-16-762-i002.jpg

1) Mean ± SD, 2) LDL-Chol: Low-density lipoprotein cholesterol, 3) HOMA-IR: Homeostasis model assessment of insulin resistance, 4) IL-6: Interleukine 6, 5) hs-CRP: High-sensitivity C-reactive protein, 6) OPG: Osteoprotegerin

Significantly different at *: p < 0.05, ***: p < 0.001 by t-test

Table 3
Dietary intakes of the subjects
kjcn-16-762-i003.jpg

1) Mean ± SD

2) Cho : Pro : Fat (%) : Carbohydrate : Protein : Fat (%)

Significantly different at *: p < 0.05 by t-test

Table 4
Relationship between OPG and cardiovascular disease risk factors and inflammatory markers
kjcn-16-762-i004.jpg

1) BMI: Body mass index, 2) SBP: Systolic blood pressure, 3) DBP: Diastolic blood pressure, 4) FPG: Fasting plasma glucose, 5) HDL-Chol: High-density lipoprotein cholesterol, 6) LDL-Chol: Low-density lipoprotein cholesterol, 7) hs-CRP: High-sensitivity C-reactive protein, 8) IL-6: Interleukine-6, 9) HOMA-IR: Homeostasis model assessment of insulin resistance

Table 5
Multiple regression of blood OPG levels on risk factors for cardiovascular disease and adiponectin
kjcn-16-762-i005.jpg

1) BMI: Body Mass Index

2) HDL-Chol: High-density lipoprotein cholesterol

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        Association of Plasma Osteoprotegerin with Adiponectin and Difference according to Obesity in Men with Metabolic Syndrome
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      Association of Plasma Osteoprotegerin with Adiponectin and Difference according to Obesity in Men with Metabolic Syndrome
      Image
      Fig. 1 Difference of OPG levels between MS group and control group according to body mass index.
      Association of Plasma Osteoprotegerin with Adiponectin and Difference according to Obesity in Men with Metabolic Syndrome

      General characteristics and metabolic syndrome indicators of the subjects

      1) Mean ± SD, 2) BMI: Body mass index, 3) WC: Waist circumference, 4) FPG: Fasting plasma glucose, 5) HDL-Chol: High-density lipoprotein cholesterol, 6) SBP: Systolic blood pressure, 7) DBP: Diastolic blood pressure

      Significantly different at **: p < 0.01, ***: p < 0.001 by t-test

      Risk factors for cardiovascular disease and inflammatory markers

      1) Mean ± SD, 2) LDL-Chol: Low-density lipoprotein cholesterol, 3) HOMA-IR: Homeostasis model assessment of insulin resistance, 4) IL-6: Interleukine 6, 5) hs-CRP: High-sensitivity C-reactive protein, 6) OPG: Osteoprotegerin

      Significantly different at *: p < 0.05, ***: p < 0.001 by t-test

      Dietary intakes of the subjects

      1) Mean ± SD

      2) Cho : Pro : Fat (%) : Carbohydrate : Protein : Fat (%)

      Significantly different at *: p < 0.05 by t-test

      Relationship between OPG and cardiovascular disease risk factors and inflammatory markers

      1) BMI: Body mass index, 2) SBP: Systolic blood pressure, 3) DBP: Diastolic blood pressure, 4) FPG: Fasting plasma glucose, 5) HDL-Chol: High-density lipoprotein cholesterol, 6) LDL-Chol: Low-density lipoprotein cholesterol, 7) hs-CRP: High-sensitivity C-reactive protein, 8) IL-6: Interleukine-6, 9) HOMA-IR: Homeostasis model assessment of insulin resistance

      Multiple regression of blood OPG levels on risk factors for cardiovascular disease and adiponectin

      1) BMI: Body Mass Index

      2) HDL-Chol: High-density lipoprotein cholesterol

      Table 1 General characteristics and metabolic syndrome indicators of the subjects

      1) Mean ± SD, 2) BMI: Body mass index, 3) WC: Waist circumference, 4) FPG: Fasting plasma glucose, 5) HDL-Chol: High-density lipoprotein cholesterol, 6) SBP: Systolic blood pressure, 7) DBP: Diastolic blood pressure

      Significantly different at **: p < 0.01, ***: p < 0.001 by t-test

      Table 2 Risk factors for cardiovascular disease and inflammatory markers

      1) Mean ± SD, 2) LDL-Chol: Low-density lipoprotein cholesterol, 3) HOMA-IR: Homeostasis model assessment of insulin resistance, 4) IL-6: Interleukine 6, 5) hs-CRP: High-sensitivity C-reactive protein, 6) OPG: Osteoprotegerin

      Significantly different at *: p < 0.05, ***: p < 0.001 by t-test

      Table 3 Dietary intakes of the subjects

      1) Mean ± SD

      2) Cho : Pro : Fat (%) : Carbohydrate : Protein : Fat (%)

      Significantly different at *: p < 0.05 by t-test

      Table 4 Relationship between OPG and cardiovascular disease risk factors and inflammatory markers

      1) BMI: Body mass index, 2) SBP: Systolic blood pressure, 3) DBP: Diastolic blood pressure, 4) FPG: Fasting plasma glucose, 5) HDL-Chol: High-density lipoprotein cholesterol, 6) LDL-Chol: Low-density lipoprotein cholesterol, 7) hs-CRP: High-sensitivity C-reactive protein, 8) IL-6: Interleukine-6, 9) HOMA-IR: Homeostasis model assessment of insulin resistance

      Table 5 Multiple regression of blood OPG levels on risk factors for cardiovascular disease and adiponectin

      1) BMI: Body Mass Index

      2) HDL-Chol: High-density lipoprotein cholesterol


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