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The Relationship between beta-cell Function and Nutrient Intakes in Korean Adult: Using 4th Korea National Health and Nutrition Examination Survey 2009
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Original Article
The Relationship between beta-cell Function and Nutrient Intakes in Korean Adult: Using 4th Korea National Health and Nutrition Examination Survey 2009
You Mi Lee, Hye Kyung Chung, Heejin Kimm, Sun Ha Jee
Korean Journal of Community Nutrition 2012;17(2):243-257.
DOI: https://doi.org/10.5720/kjcn.2012.17.2.243
Published online: April 30, 2012

Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.

1Department of Nutrition Services, Kangnam Severance Hospital, Yonsei University, Seoul, Korea.

Corresponding author: Kimm Heejin, Graduate School of Public Health, Yonsei University, 50 Yonsei-no, Seodaemun-gu, Seoul 120-752, Korea. Tel: (02) 2228-1531, Fax: (02) 365-5118, HEEJINK@yuhs.ac
• Received: February 13, 2012   • Revised: March 21, 2012   • Accepted: March 30, 2012

Copyright © 2012 The Korean Society of Community Nutrition

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  • The purpose of this study was to evaluate pancreatic β-cell function of Korean adult and to examine the associations between β-cell function and nutrient intakes. Data were analyzed for 1,917 male and 2,885 female subjects older than 30 years using 'The Forth Korean National Health and Nutrition Survey in 2009'. We calculated HOMA β-cell (The homeostasis model assessment of β-cell function) using fasting glucose and fasting insulin for assessing β-cell function. Subjects were divided into HHG (High HOMA β-cell Group) or LHG (Low HOMA β-cell Group) according to median of HOMA β-cell, and then nutrient intakes were compared between two groups. In the entire study population, HHG showed lower percent of carbohydrate intakes (p < 0.05), and higher fat (p < 0.01), percent of fat (p < 0.05), vitamin A (p < 0.05), carotene (p < 0.05) and riboflavin (p < 0.05) intakes than LHG. In addition, levels of HOMA β-cell were negatively correlated with percent of carbohydrate (β = -0.040, p < 0.05), and positively correlated with percent of fat (β = 0.046, p < 0.01). The subjects were then divided into two subgroups according to body mass index values, either < 23 kg/m2 (under- and normal-weight) or ≥ 23 kg/m2 (over-weight and obese). Significant differences of some nutrients intakes and correlations with HOMA β-cell were observed only in under- and normal weight subjects, but not in over-weight and obese subjects. In conclusion, high carbohydrate, lower fat and lower vitamin intakes may be related with pancreatic β-cell dysfunction in under- and normal-weight Korean.

This research was supported by Basic Science Research Program Through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (14245).

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Fig. 1
The means of HOMA β-cell level according to age and sex.
HOMA β-cell: The homeostasis model assessment of β-cell function.
p-values: t-test between male and female.
kjcn-17-243-g001.jpg
Table 1
Anthropometric measurements and metabolic characteristics of subjects
kjcn-17-243-i001.jpg

1) LHG: Low HOMA β-cell group

2) HHG: High HOMA β-cell group. Low and high HOMA-β-cell groups were divided by median cut point (107.36 for total subjects, 102.18 for male subjects, 111.43 for female subjects)

3) p-values: t-test between LHG and HHG

4) Data are Mean ± SD

5) BMI: Body Mass Index

6) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

7) HOMA-IR: The homeostasis model assessment of insulin resistance. The values of HOMA IR were analyzed after log transformed

Table 2
Correlation coefficients between HOMA β-cell and anthropometric and metabolic variables in subjects
kjcn-17-243-i002.jpg

1) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

2) BMI: Body Mass Index

Table 3
Comparison of nutrient intakes between low HOMA β-cell group and high HOMA β-cell group
kjcn-17-243-i003.jpg

1) LHG: Low HOMA β-cell Group

2) HHG: High HOMA β-cell Group. Low and high HOMA-β-cell groups were divided by median cut point (107.36 for total subjects, 102.18 for male subjects, 111.43 for female subjects)

3) p-values: t-test between LHG and HHG

4) Data are Mean ± SD

Table 4
Correlation coefficients between HOMA β-cell and nutrient intakes in subjects
kjcn-17-243-i004.jpg

1) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

Table 5
Comparison of nutrient intakes between low HOMA β-cell group and high HOMA β-cell group according to BMI
kjcn-17-243-i005.jpg

1) BMI: Body Mass Index

2) LHG: Low HOMA β-cell Group

3) HHG: High HOMA β-cell Group. Low and high HOMA-β-cell groups were divided by median cut point (100.46 for under-and normal-weight subjects, 112.11 for over-weight and obesity subjects)

4) p-values: t-test between LHG and HHG

5) Data are Mean ± SD

Table 6
Correlation coefficients between HOMA β-cell and nutrient intakes according to body mass index
kjcn-17-243-i006.jpg

1) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

2) BMI: Body Mass Index

Figure & Data

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    The Relationship between beta-cell Function and Nutrient Intakes in Korean Adult: Using 4th Korea National Health and Nutrition Examination Survey 2009
    Image
    Fig. 1 The means of HOMA β-cell level according to age and sex. HOMA β-cell: The homeostasis model assessment of β-cell function. p-values: t-test between male and female.
    The Relationship between beta-cell Function and Nutrient Intakes in Korean Adult: Using 4th Korea National Health and Nutrition Examination Survey 2009

    Anthropometric measurements and metabolic characteristics of subjects

    1) LHG: Low HOMA β-cell group

    2) HHG: High HOMA β-cell group. Low and high HOMA-β-cell groups were divided by median cut point (107.36 for total subjects, 102.18 for male subjects, 111.43 for female subjects)

    3) p-values: t-test between LHG and HHG

    4) Data are Mean ± SD

    5) BMI: Body Mass Index

    6) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

    7) HOMA-IR: The homeostasis model assessment of insulin resistance. The values of HOMA IR were analyzed after log transformed

    Correlation coefficients between HOMA β-cell and anthropometric and metabolic variables in subjects

    1) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

    2) BMI: Body Mass Index

    Comparison of nutrient intakes between low HOMA β-cell group and high HOMA β-cell group

    1) LHG: Low HOMA β-cell Group

    2) HHG: High HOMA β-cell Group. Low and high HOMA-β-cell groups were divided by median cut point (107.36 for total subjects, 102.18 for male subjects, 111.43 for female subjects)

    3) p-values: t-test between LHG and HHG

    4) Data are Mean ± SD

    Correlation coefficients between HOMA β-cell and nutrient intakes in subjects

    1) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

    Comparison of nutrient intakes between low HOMA β-cell group and high HOMA β-cell group according to BMI

    1) BMI: Body Mass Index

    2) LHG: Low HOMA β-cell Group

    3) HHG: High HOMA β-cell Group. Low and high HOMA-β-cell groups were divided by median cut point (100.46 for under-and normal-weight subjects, 112.11 for over-weight and obesity subjects)

    4) p-values: t-test between LHG and HHG

    5) Data are Mean ± SD

    Correlation coefficients between HOMA β-cell and nutrient intakes according to body mass index

    1) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

    2) BMI: Body Mass Index

    Table 1 Anthropometric measurements and metabolic characteristics of subjects

    1) LHG: Low HOMA β-cell group

    2) HHG: High HOMA β-cell group. Low and high HOMA-β-cell groups were divided by median cut point (107.36 for total subjects, 102.18 for male subjects, 111.43 for female subjects)

    3) p-values: t-test between LHG and HHG

    4) Data are Mean ± SD

    5) BMI: Body Mass Index

    6) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

    7) HOMA-IR: The homeostasis model assessment of insulin resistance. The values of HOMA IR were analyzed after log transformed

    Table 2 Correlation coefficients between HOMA β-cell and anthropometric and metabolic variables in subjects

    1) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

    2) BMI: Body Mass Index

    Table 3 Comparison of nutrient intakes between low HOMA β-cell group and high HOMA β-cell group

    1) LHG: Low HOMA β-cell Group

    2) HHG: High HOMA β-cell Group. Low and high HOMA-β-cell groups were divided by median cut point (107.36 for total subjects, 102.18 for male subjects, 111.43 for female subjects)

    3) p-values: t-test between LHG and HHG

    4) Data are Mean ± SD

    Table 4 Correlation coefficients between HOMA β-cell and nutrient intakes in subjects

    1) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

    Table 5 Comparison of nutrient intakes between low HOMA β-cell group and high HOMA β-cell group according to BMI

    1) BMI: Body Mass Index

    2) LHG: Low HOMA β-cell Group

    3) HHG: High HOMA β-cell Group. Low and high HOMA-β-cell groups were divided by median cut point (100.46 for under-and normal-weight subjects, 112.11 for over-weight and obesity subjects)

    4) p-values: t-test between LHG and HHG

    5) Data are Mean ± SD

    Table 6 Correlation coefficients between HOMA β-cell and nutrient intakes according to body mass index

    1) HOMA β-cell: The homeostasis model assessment of β-cell function. The values of HOMA β-cell were analyzed after log transformed

    2) BMI: Body Mass Index


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